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Image Search Results
Journal: Oncotarget
Article Title: Comparative evaluation of three proliferation markers, Ki-67, TOP2A, and RacGAP1, in bronchopulmonary neuroendocrine neoplasms: Issues and prospects
doi: 10.18632/oncotarget.9747
Figure Lengend Snippet: The boxplots are depicting the Ki-67 protein (left) and mRNA (right) levels in the different BP-NEN entities as evaluated by immunohistochemistry and by RT-qPCR. The different Ki-67-IHC evlauation methods are represented by different shades of grey: The Ki-67-Average is depicted by the first box in light grey, the Ki-67-Hotspots are illustrated in slightly darker grey and the last dark grey box stands for the IHC Ki-67 levels as determined by the fully automated digital image analysis. Beneath the respective Kaplan-Meier-Analyses are shown. Blue indicates low, green moderate and red high Ki-67 expression levels in each evaluation method, according to the cut-off limits of the ROC analysis between TC – AC and AC – SCLC. High Ki-67 expression levels correlate with a poor survival of the patients.
Article Snippet: The adjacent 4-μm-paraffin sections of the immunohistochemical investigations of randomly selected 17 TC, 19 AC, 41 SCLC (13 with poor prognosis and 24 with good prognosis) and 7 LCNEC were analyzed for
Techniques: Immunohistochemistry, Quantitative RT-PCR, Expressing